What is the weight loss principle of vine fruit extract?

The weight loss of Garcinia is mainly attributed to hydroxycitric acid (HCA), which exists in the skin or exocarp of Garcinia, accounting for 20-30% of the dry weight. It was reported that obese rats were fed 500 mg HCA twice a day. The results showed that taking HCA could promote the weight loss of rats, reduce the amount of fat, visceral fat, total cholesterol and blood glucose curve. The weight loss mechanism of HCA in Garcinia tenuifolia discussed by the researchers is mainly as follows:

(1) HCA is a competitive inhibitor of ATP citrate lyase. It catalyzes the decomposition of citric acid into oxalate and acetyl coenzyme a in vitro, which limits the utilization of acetyl coenzyme a. Acetyl coenzyme a plays a key role in the synthesis of fatty acids in carbohydrate rich diets. Therefore, HCA can inhibit the synthesis of body fat.

(2) In addition, the increase of citric acid not converted to acetyl coenzyme a will accelerate the glycogen production of glucose. Therefore, the intake of HCA can also stabilize the glucose level in the blood, thereby inhibiting hunger and reducing intake.